Establishment or maintenance of cytoskeleton polarity

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, NASP, and LIG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of cytoskeleton polarity activity versus SMC1A in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SMC1A →	+0.232	+0.076	<.001	<.001	3	6
HNSC	NASP →	+0.459	+0.151	<.001	<.001	3	6
LUAD	LIG1 →	+0.364	+0.054	.001	<.001	3	6
HNSC	SETDB1_S1066 →	+0.407	+0.063	<.001	.002	3	6
PDAC	TRIM28 →	+0.128	+0.042	.005	.005	3	5
OV	NUF2 →	+0.562	+0.066	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030952 vs SMC1A — COAD

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