Establishment or maintenance of cytoskeleton polarity

Across TCGA pan-cancer cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Establishment or maintenance of cytoskeleton polarity pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and KIRP, show the opposite pattern, with higher activity associated with better survival.

MESO, HNSC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.392	0.655	<.001	129	view →
HNSC	DFS	Median	III,IV	0.763	0.597	<.001	118	view →
ACC	OS	Tertile	All	0.376	0.752	<.001	100	view →
LGG	DFS	Median	All	0.774	0.878	<.001	43	view →
SARC	OS	Quartile	All	0.404	0.788	<.001	26	view →
KIRP	DFS	Quartile	III,IV	0.809	0.062	.004	26	view →
READ	OS	Tertile	III,IV	0.609	0.285	.013	24	view →
ESCA	OS	Quartile	All	0.465	0.736	.006	22	view →
LIHC	OS	Tertile	II,III,IV	0.303	0.532	.004	17	view →
COAD	OS	Median	II,III,IV	0.717	0.837	.005	15	view →
CHOL	DFS	Median	All	0.229	0.722	.002	15	view →
OV	OS	Tertile	All	0.795	0.897	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0030952–MESO (OS)

Open the MESO breakdown →