Paranodal junction assembly

Across TCGA cell cohorts, RNA activity of the Paranodal junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C1, SCYL1, and SART1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H4C1 grouped by Paranodal junction assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H4C1 →	-0.619	-0.829	<.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	SCYL1 →	-0.997	-0.977	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	SART1 →	-1.102	-0.969	.008	.007	2	6
BLOOD_Myeloma	ZNF530 →	-1.763	-1.483	.003	.007	3	5
BLOOD_Myeloma	FPGS →	-1.099	-1.337	<.001	<.001	3	5
BLOOD_Myeloma	ZNRD2 →	-1.492	-1.562	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H4C1 by Paranodal junction assembly activity — LARGE_INTESTINE

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