Paranodal junction assembly

Across TCGA pan-cancer cohorts, RNA activity of the Paranodal junction assembly pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher Paranodal junction assembly pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

LUSC, LUAD, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.735	0.584	<.001	52	view →
LUAD	DFS	Tertile	II,III,IV	0.856	0.652	.004	50	view →
BLCA	OS	Quartile	II,III,IV	0.713	0.551	.006	38	view →
PAAD	DFS	Quartile	All	0.568	0.266	.001	34	view →
SARC	OS	Tertile	All	0.838	0.551	<.001	24	view →
CESC	DFS	Median	All	0.776	0.862	.034	10	view →
READ	DFS	Median	All	0.636	0.434	.010	10	view →
KIRC	DFS	Median	All	0.842	0.908	.019	9	view →
SKCM	DFS	Median	IV	0.062	0.641	.003	9	view →
THCA	OS	Tertile	IV	0.520	0.784	.014	7	view →
UCS	DFS	Tertile	III,IV	0.471	0.145	.021	6	view →
STAD	DFS	Quartile	II,III,IV	0.552	0.815	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0030913–LUSC (OS)

Open the LUSC breakdown →