Female genitalia development

Across TCGA cell cohorts, RNA activity of the Female genitalia development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C3, IL27, and CES2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H3C3 grouped by Female genitalia development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	H3C3 →	-0.122	-0.800	.003	.005	3	3
CNS	IL27 →	-0.261	-0.738	<.001	.009	3	3
BLOOD_Leukemia	CES2 →	-0.160	-1.035	.003	.004	3	3
LUNG_SCLC	CCNA2 →	+0.194	+0.957	.008	.003	3	3
LUNG_SCLC	ILK →	-0.280	-1.336	.004	.003	3	3
LUNG_SCLC	TRIM49C →	+0.346	+1.344	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H3C3 by Female genitalia development activity — OVARY

Explore this box plot interactively →