Female genitalia development

Across TCGA pan-cancer cohorts, RNA activity of the Female genitalia development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Female genitalia development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCEC, show the opposite pattern, with higher activity associated with better survival.

HNSC, UCEC, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.738	0.546	.003	36	view →
UCEC	OS	Tertile	IV	0.881	0.532	.007	28	view →
OV	DFS	Tertile	III,IV	0.574	0.496	.013	26	view →
LUAD	DFS	Quartile	IV	0.198	0.788	.012	22	view →
LUSC	DFS	Median	III,IV	0.201	0.496	.002	18	view →
PAAD	OS	Tertile	II,III,IV	0.584	0.255	.004	18	view →
SARC	OS	Quartile	All	0.724	0.878	.004	17	view →
UVM	DFS	Tertile	III,IV	0.267	0.769	.024	16	view →
THYM	DFS	Median	All	0.734	0.947	.008	16	view →
THCA	DFS	Median	All	0.937	0.711	.007	14	view →
CHOL	DFS	Tertile	III,IV	0.174	0.779	.024	12	view →
SKCM	DFS	Tertile	III,IV	0.379	0.577	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0030540–HNSC (DFS)

Open the HNSC breakdown →