Intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CC, SYT8, and H3-3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus PPP1CC in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP1CC →	+0.344	+0.154	<.001	<.001	3	5
LSCC	SYT8 →	-0.996	-0.129	.002	.006	3	4
HNSC	H3-3A →	+0.534	+0.131	<.001	.004	3	4
HNSC	SLC25A40 →	+0.402	+0.086	.004	.002	3	4
LUAD	ARID2 →	+0.267	+0.158	.003	.006	3	4
BRCA	NIPAL4 →	-0.423	-0.164	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs PPP1CC — CCRCC

Explore this scatter interactively →