Intracellular estrogen receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Intracellular estrogen receptor signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and BRCA, show the opposite pattern, with higher activity associated with better survival.

LIHC, SCLC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Quartile	II,III,IV	0.206	0.575	.001	48	view →
SCLC	OS	Tertile	All	0.837	0.519	<.001	47	view →
LGG	DFS	Median	All	0.321	0.461	<.001	41	view →
BRCA	DFS	Median	III,IV	0.867	0.716	<.001	35	view →
READ	OS	Median	All	0.799	0.309	.010	29	view →
HNSC	DFS	Tertile	III,IV	0.468	0.262	.006	25	view →
DLBC	DFS	Tertile	All	0.625	1.000	.005	22	view →
LUSC	DFS	Quartile	III,IV	0.489	0.961	.020	16	view →
OV	OS	Median	III,IV	0.783	0.873	.016	12	view →
SKCM	OS	Median	All	0.292	0.523	.014	10	view →
PAAD	DFS	Tertile	All	0.548	0.313	.015	8	view →
UVM	DFS	Median	All	0.280	0.589	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0030520–LIHC (OS)

Open the LIHC breakdown →