Intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX19A, MYO18A, and TAMALIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus DDX19A in PANCREAS (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DDX19A →	-0.617	-0.155	.004	<.001	3	4
OVARY	MYO18A →	-1.268	-0.136	.001	<.001	3	4
OESOPHAGUS	TAMALIN →	+0.604	+0.102	.004	.002	3	4
URINARY_TRACT	C10orf95 →	+0.767	+0.133	<.001	.005	3	4
OESOPHAGUS	KCNIP2 →	+1.035	+0.168	<.001	<.001	3	4
KIDNEY	MXD3 →	+1.056	+0.217	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs DDX19A — PANCREAS

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