Negative regulation of transforming growth factor beta receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of transforming growth factor beta receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, EFEMP2, and ISLR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta receptor signaling pathway activity versus SORBS3 in CCRCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS3 →	+0.514	+0.038	<.001	<.001	3	9
CCRCC	EFEMP2 →	+0.551	+0.033	.004	<.001	3	9
GBM	ISLR →	+0.732	+0.041	<.001	<.001	3	9
BRCA	OLFML3 →	+0.767	+0.039	<.001	<.001	3	9
CCRCC	PALM2AKAP2 →	+0.520	+0.034	<.001	<.001	3	9
UCEC	RSU1 →	+0.409	+0.041	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030512 vs SORBS3 — CCRCC

Explore this scatter interactively →