Negative regulation of transforming growth factor beta receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of transforming growth factor beta receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECSIT, MCM7, and THRAP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta receptor signaling pathway activity versus ECSIT in OVARY (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ECSIT →	+0.788	+1.269	<.001	.001	3	6
BREAST	MCM7 →	+0.562	+1.015	.002	.003	3	6
BREAST	THRAP3 →	+0.623	+1.349	.001	.001	3	5
BREAST	NASP →	+1.031	+1.519	.003	<.001	3	5
PANCREAS	SF3A3 →	+0.842	+1.503	.009	.002	2	6
PANCREAS	PTPRA →	+0.637	+1.062	.006	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030512 vs ECSIT — OVARY

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