Nuclear migration along microtubule

Across TCGA cell cohorts, RNA activity of the Nuclear migration along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1B, TRAP1, and BCL7A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration along microtubule activity versus ATP5F1B in BONE (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ATP5F1B →	-1.074	-1.803	.002	<.001	3	7
BONE	TRAP1 →	-1.496	-1.949	.001	<.001	3	7
BONE	BCL7A →	-1.569	-1.724	.003	<.001	3	6
BONE	AIFM1 →	-0.973	-1.616	.004	<.001	3	6
BONE	IGFBP7 →	+6.513	+1.793	.005	.001	3	6
BONE	SFXN4 →	-1.059	-1.562	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030473 vs ATP5F1B — BONE

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