Nuclear migration along microtubule

Across TCGA pan-cancer cohorts, RNA activity of the Nuclear migration along microtubule pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher Nuclear migration along microtubule pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and HNSC, show the opposite pattern, with higher activity associated with better survival.

LUSC, BLCA, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.822	0.659	<.001	61	view →
BLCA	DFS	Median	All	0.450	0.559	.009	35	view →
HNSC	OS	Tertile	All	0.817	0.714	.010	35	view →
STAD	OS	Median	All	0.738	0.638	.013	25	view →
KICH	OS	Quartile	All	0.780	1.000	.008	24	view →
MESO	DFS	Quartile	All	0.251	0.910	.006	21	view →
UCS	DFS	Tertile	II,III,IV	0.130	0.552	.005	18	view →
OV	DFS	Median	All	0.577	0.506	.012	18	view →
COAD	DFS	Tertile	III,IV	0.559	0.124	.002	16	view →
KIRP	DFS	Quartile	All	1.000	0.577	.008	16	view →
TGCT	DFS	Median	All	0.924	0.754	.006	14	view →
UVM	DFS	Quartile	II,III,IV	0.487	0.876	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0030473–LUSC (OS)

Open the LUSC breakdown →