Skeletal muscle thin filament assembly

Across TCGA cell cohorts, RNA activity of the Skeletal muscle thin filament assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT1, FAM43A, and AKR1C1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT1 grouped by Skeletal muscle thin filament assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACOT1 →	-0.216	-1.835	.008	<.001	3	1
LARGE_INTESTINE	FAM43A →	+0.260	+1.833	.002	.004	3	1
LARGE_INTESTINE	AKR1C1 →	-0.233	-1.929	.002	<.001	3	1
LARGE_INTESTINE	DHRS2 →	+0.163	+1.929	.004	<.001	3	1
LARGE_INTESTINE	CXCL12 →	+0.146	+1.953	.002	.001	3	1
LARGE_INTESTINE	NR4A3 →	-0.073	-1.893	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT1 by Skeletal muscle thin filament assembly activity — LARGE_INTESTINE

Explore this box plot interactively →