Heparin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Heparin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMB1, DSE, and GPX1P2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin biosynthetic process activity versus LAMB1 in GBM (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LAMB1 →	+0.726	+0.686	<.001	<.001	3	5
PDAC	DSE →	+0.374	+0.500	.003	.003	2	4
PDAC	GPX1P2 →	+0.210	+0.348	.001	.004	3	3
COAD	EEF1A1P4 →	+0.766	+0.604	.003	.005	3	3
UCEC	ARHGEF6 →	-0.617	-0.578	.002	.008	3	3
UCEC	P2RY8 →	-0.620	-0.640	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030210 vs LAMB1 — GBM

Explore this scatter interactively →