Heparin biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Heparin biosynthetic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Heparin biosynthetic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and THCA, show the opposite pattern, with higher activity associated with better survival.

LGG, BLCA, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.745	0.878	<.001	50	view →
BLCA	DFS	Median	All	0.197	0.462	.001	43	view →
KIRP	OS	Quartile	II,III,IV	0.153	0.682	.018	32	view →
KIRC	OS	Median	All	0.898	0.849	.003	25	view →
CESC	OS	Median	III,IV	0.300	0.605	.022	20	view →
THCA	DFS	Tertile	II,III,IV	0.928	0.766	.010	20	view →
CHOL	DFS	Quartile	All	0.083	0.838	.008	14	view →
PAAD	DFS	Median	III,IV	0.370	0.853	.010	12	view →
PRAD	DFS	Tertile	All	0.902	0.727	.014	12	view →
SKCM	DFS	Median	III,IV	0.491	0.683	.012	11	view →
TGCT	DFS	Median	All	0.537	0.768	.013	8	view →
LAML	DFS	Quartile	All	0.720	0.460	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0030210–LGG (OS)

Open the LGG breakdown →