Heparin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Heparin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLCE_S73, TYMP_S50, and EXT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin biosynthetic process activity versus GLCE_S73 in LUAD (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GLCE_S73 →	+1.067	+0.482	<.001	.008	1	6
OV	TYMP_S50 →	+0.711	+0.393	<.001	.003	3	3
OV	EXT1 →	+0.696	+0.612	<.001	.002	2	4
UCEC	GLCE →	+0.583	+0.796	<.001	<.001	3	3
OV	SUPT6H_S1701 →	-1.174	-0.345	<.001	<.001	3	3
UCEC	KIAA1109_T3996 →	+0.360	+0.726	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030210 vs GLCE_S73 — LUAD

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