Heparin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Heparin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H4, THADA, and ZP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2H4 grouped by Heparin biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GTF2H4 →	+0.811	+1.331	.003	.002	3	3
SOFT_TISSUE	THADA →	-1.041	-1.500	.003	.005	3	3
SOFT_TISSUE	ZP3 →	+1.609	+1.163	.002	.003	3	3
BONE	ANXA13 →	-0.135	-1.567	.007	.004	3	3
BONE	RIPK4 →	+3.157	+1.783	.001	.006	3	3
SKIN	MBD4 →	+0.399	+1.210	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2H4 by Heparin biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →