Heparin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Heparin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP9, LSM7, and SMYD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparin biosynthetic process activity versus RRP9 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RRP9 →	+0.547	+1.219	<.001	.001	3	5
OVARY	LSM7 →	+0.635	+0.979	.002	<.001	3	5
LIVER	SMYD5 →	+0.916	+1.330	.002	.001	3	5
PANCREAS	DBF4 →	+0.860	+1.506	.007	.006	3	5
PANCREAS	TANGO6 →	+1.219	+1.371	<.001	<.001	3	5
PANCREAS	RSL1D1 →	+0.609	+1.211	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030210 vs RRP9 — LARGE_INTESTINE

Explore this scatter interactively →