Sphingolipid catabolic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF23, NUP205, and PBK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid catabolic process activity versus KIF23 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF23 →	-0.629	-0.127	.001	.005	3	5
LSCC	NUP205 →	-0.404	-0.135	<.001	<.001	3	5
LSCC	PBK →	-0.844	-0.173	<.001	<.001	3	5
LSCC	CDC7 →	-0.842	-0.215	<.001	<.001	3	5
LSCC	ARHGAP11A →	-0.705	-0.196	<.001	<.001	3	5
LSCC	NPM1P9 →	-0.696	-0.174	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030149 vs KIF23 — LSCC

Explore this scatter interactively →