Sphingolipid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Sphingolipid catabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 32 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Sphingolipid catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and DLBC, show the opposite pattern, with higher activity associated with better survival.

BRCA, KIRC, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.978	0.948	<.001	78	view →
KIRC	DFS	Quartile	All	0.486	0.828	<.001	52	view →
LIHC	OS	Quartile	All	0.405	0.653	.001	51	view →
DLBC	DFS	Median	All	1.000	0.615	.001	44	view →
PAAD	DFS	Median	All	0.622	0.383	.003	32	view →
PRAD	DFS	Median	All	0.939	0.846	<.001	24	view →
MESO	OS	Tertile	All	0.189	0.439	.020	18	view →
ACC	OS	Median	II,III,IV	0.843	0.451	.018	15	view →
LUSC	OS	Median	All	0.326	0.453	.009	12	view →
STAD	DFS	Tertile	IV	0.087	0.437	.017	6	view →
READ	OS	Median	IV	0.702	1.000	.008	6	view →
HNSC	DFS	Quartile	II,III,IV	0.637	0.366	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0030149–BRCA (OS)

Open the BRCA breakdown →