Sphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC3, RIF1_S782, and RRP36_S73, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid biosynthetic process activity versus RFC3 in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	-0.288	-0.040	<.001	<.001	3	8
GBM	RIF1_S782 →	-0.648	-0.041	<.001	<.001	3	8
GBM	RRP36_S73 →	-0.866	-0.056	<.001	<.001	3	8
OV	WDR43_S77 →	-1.030	-0.023	.001	.001	3	8
BRCA	DDX18 →	-0.486	-0.021	<.001	<.001	3	8
BRCA	NIFK →	-0.372	-0.020	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030148 vs RFC3 — GBM

Explore this scatter interactively →