Sphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIMS3, SDCBPP1, and RNU6-87P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid biosynthetic process activity versus RIMS3 in HNSC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RIMS3 →	-0.615	-0.119	.003	.001	3	3
GBM	SDCBPP1 →	+0.385	+0.157	.005	.003	3	3
HNSC	RNU6-87P →	+0.915	+0.127	.001	.007	3	3
HNSC	CRLF1 →	-0.682	-0.141	<.001	<.001	3	3
COAD	RNU6-767P →	+0.572	+0.171	.006	.004	3	3
GBM	RRN3P2 →	+0.323	+0.285	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030148 vs RIMS3 — HNSC

Explore this scatter interactively →