Intracellular monoatomic anion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM107B, CYP27A1, and WDHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular monoatomic anion homeostasis activity versus FAM107B in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAM107B →	+0.615	+0.079	.001	.004	3	7
LSCC	CYP27A1 →	+0.661	+0.119	<.001	<.001	3	7
LUAD	WDHD1 →	-0.564	-0.075	<.001	.002	3	6
GBM	REPS2_S493 →	+0.693	+0.073	<.001	<.001	3	6
GBM	ASAH1 →	+0.404	+0.080	<.001	<.001	3	6
UCEC	ACSL4 →	+0.412	+0.092	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030002 vs FAM107B — GBM

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