Intracellular monoatomic anion homeostasis

Across TCGA pan-cancer cohorts, RNA activity of the Intracellular monoatomic anion homeostasis pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Intracellular monoatomic anion homeostasis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SCLC, SKCM, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.182	0.520	.003	52	view →
SKCM	OS	Quartile	II,III,IV	0.513	0.264	.001	42	view →
ESCA	OS	Quartile	All	0.401	1.000	.002	30	view →
HNSC	DFS	Median	III,IV	0.403	0.275	.016	22	view →
COAD	DFS	Median	All	0.732	0.818	.006	16	view →
THYM	OS	Tertile	All	0.773	1.000	.004	14	view →
KICH	DFS	Median	II,III,IV	0.375	0.928	.004	13	view →
SARC	DFS	Quartile	All	0.149	0.449	<.001	13	view →
UVM	OS	Median	III,IV	0.929	0.473	.011	13	view →
KIRC	DFS	Median	III,IV	0.793	0.688	.014	12	view →
READ	DFS	Median	IV	0.366	0.769	.011	12	view →
BLCA	OS	Quartile	All	0.219	0.504	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0030002–SCLC (OS)

Open the SCLC breakdown →