Extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF3C2, TBC1D8B, and CAPN7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF3C2 grouped by Extracellular matrix disassembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GTF3C2 →	+0.582	+1.499	.005	.002	3	6
LUNG_NSCLC_LUSC	TBC1D8B →	-1.392	-2.027	.003	<.001	3	4
BLOOD_Lymphoma	CAPN7 →	+0.597	+1.479	.005	.002	3	4
BLOOD_Lymphoma	RAD9A →	+0.950	+1.448	.002	<.001	3	4
PANCREAS	CLDND1 →	-0.691	-1.063	.004	<.001	3	4
BREAST	WDR74 →	+0.428	+0.825	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF3C2 by Extracellular matrix disassembly activity — BLOOD_Lymphoma

Explore this box plot interactively →