Hypothalamus cell differentiation

Across TCGA cell cohorts, RNA activity of the Hypothalamus cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELP, MED15, and AGAP7P, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELP grouped by Hypothalamus cell differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SELP →	-0.278	-0.216	<.001	.002	3	6
BREAST	MED15 →	-0.167	-0.176	.001	.003	3	4
URINARY_TRACT	AGAP7P →	-0.192	-0.285	.005	.002	3	4
CNS	EMP2 →	-0.142	-0.142	.006	.007	3	4
SOFT_TISSUE	NMBR →	-0.243	-0.357	.005	.005	3	4
SOFT_TISSUE	SCYL1 →	-0.190	-0.317	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELP by Hypothalamus cell differentiation activity — LIVER

Explore this box plot interactively →