Hindbrain radial glia guided cell migration

Across TCGA cell cohorts, RNA activity of the Hindbrain radial glia guided cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF4, BTN3A3, and ZNF430, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain radial glia guided cell migration activity versus RASSF4 in LUNG_SCLC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RASSF4 →	+0.960	+0.356	.003	.004	2	2
LUNG_SCLC	BTN3A3 →	+1.768	+0.363	.001	.002	3	1
LUNG_SCLC	ZNF430 →	-1.234	-0.331	.009	.004	3	1
LUNG_SCLC	AHNAK →	+3.672	+0.360	.004	.001	3	1
LUNG_SCLC	TUBGCP6 →	+1.256	+0.361	.008	.003	3	1
LUNG_SCLC	GIT2 →	+1.067	+0.428	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021932 vs RASSF4 — LUNG_SCLC

Explore this scatter interactively →