Hindbrain radial glia guided cell migration

Across TCGA pan-cancer cohorts, RNA activity of the Hindbrain radial glia guided cell migration pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Hindbrain radial glia guided cell migration pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and KIRP, show the opposite pattern, with higher activity associated with better survival.

BRCA, LGG, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.874	0.715	<.001	60	view →
LGG	OS	Median	All	0.738	0.870	<.001	48	view →
KIRP	DFS	Tertile	III,IV	0.845	0.231	.002	42	view →
LUAD	DFS	Tertile	III,IV	0.708	0.409	.004	42	view →
LUSC	OS	Tertile	All	0.768	0.594	<.001	36	view →
UCS	DFS	Tertile	IV	0.230	0.818	.038	24	view →
LIHC	OS	Tertile	All	0.679	0.815	.006	18	view →
CESC	DFS	Quartile	III,IV	0.313	0.806	.021	14	view →
KIRC	DFS	Quartile	IV	0.253	0.697	.020	10	view →
UCEC	OS	Quartile	All	0.843	0.626	.026	6	view →
SCLC	DFS	Median	All	0.539	0.302	.016	6	view →
ACC	OS	Tertile	IV	0.903	0.498	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0021932–BRCA (DFS)

Open the BRCA breakdown →