Smoothened signaling pathway involved in ventral spinal cord patterning

pathway activity — cross-omics
GO:0021910Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Smoothened signaling pathway involved in ventral spinal cord patterning pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLI3_S980, SPINDOC, and GLI3_S865, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVGLI3_S980 →+1.355+0.350<.001.00625
HNSCSPINDOC →+0.608+0.259.001.00133
OVGLI3_S865 →+0.946+0.504<.001<.00133
OVPPP2R3A_S692 →+1.013+0.308<.001.00133
LSCCAHDC1_S1507 →+0.534+0.340.003.00324
OVDENND5A_T1079 →+2.154+0.872<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration