Hypothalamus gonadotrophin-releasing hormone neuron differentiation

Across TCGA cell cohorts, RNA activity of the Hypothalamus gonadotrophin-releasing hormone neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP4, TSPAN5, and CASP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypothalamus gonadotrophin-releasing hormone neuron differentiation activity versus MPP4 in BREAST (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MPP4 →	+1.695	+2.070	<.001	.006	3	4
LIVER	TSPAN5 →	+3.135	+1.702	.007	.001	2	4
PANCREAS	CASP1 →	-3.476	-1.671	.008	<.001	3	2
PANCREAS	MAP4K4 →	+1.303	+1.423	<.001	.003	3	2
LUNG_NSCLC_LUAD	LGALS1 →	+0.990	+1.152	.009	.009	3	2
LUNG_NSCLC_LUAD	GSKIP →	+1.407	+1.835	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021886 vs MPP4 — BREAST

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