Hypothalamus gonadotrophin-releasing hormone neuron differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Hypothalamus gonadotrophin-releasing hormone neuron differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Hypothalamus gonadotrophin-releasing hormone neuron differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and UVM, show the opposite pattern, with higher activity associated with better survival.

MESO, SKCM, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.285	0.466	.003	71	view →
SKCM	OS	Tertile	II,III,IV	0.421	0.186	<.001	54	view →
KIRC	DFS	Median	All	0.560	0.687	<.001	52	view →
UVM	DFS	Quartile	II,III,IV	0.727	0.343	.003	36	view →
LUSC	DFS	Tertile	III,IV	0.249	1.000	.003	36	view →
KIRP	OS	Quartile	II,III,IV	0.330	0.809	.012	25	view →
STAD	DFS	Tertile	III,IV	0.186	0.502	.020	23	view →
PAAD	OS	Median	All	0.523	0.713	.017	19	view →
DLBC	DFS	Quartile	II,III,IV	0.118	1.000	.010	16	view →
UCS	OS	Tertile	IV	0.679	0.308	.024	12	view →
PCPG	DFS	Tertile	All	1.000	0.794	.001	11	view →
LGG	OS	Tertile	All	0.833	0.902	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0021886–MESO (OS)

Open the MESO breakdown →