Forebrain neuron differentiation

Across TCGA patient cohorts, RNA activity of the Forebrain neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POSTN, TIMP2, and TRIO_S2440, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain neuron differentiation activity versus POSTN in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POSTN →	+0.636	+0.055	.009	.009	3	7
BRCA	TIMP2 →	+0.580	+0.033	.001	.001	3	6
PDAC	TRIO_S2440 →	+0.554	+0.031	<.001	.001	3	6
OV	LRP1 →	+0.416	+0.051	.002	.002	3	6
PDAC	HTRA1 →	+0.492	+0.037	<.001	<.001	3	6
BRCA	PDLIM3 →	+0.456	+0.035	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021879 vs POSTN — UCEC

Explore this scatter interactively →