Forebrain neuron differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Forebrain neuron differentiation pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and UCEC, show the opposite pattern, with lower activity in tumor tissue.

LUAD, UCEC, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	All	III,IV	−0.062	<.001	9	view →
UCEC	All	All	−0.059	<.001	8	view →
LIHC	Male	All	−0.031	<.001	8	view →
LUSC	Male	II,III,IV	−0.104	<.001	7	view →
KICH	Female	II,III,IV	+0.071	<.001	6	view →
KIRP	All	II,III,IV	−0.040	.003	6	view →
BLCA	Male	All	−0.045	.008	4	view →
KIRC	All	II,III,IV	−0.014	.010	4	view →
PAAD	All	All	−0.045	.039	2	view →
PRAD	All	All	−0.022	.013	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0021879–LUAD

Open the LUAD breakdown →