Forebrain neuroblast division

pathway activity — cross-omics
GO:0021873Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Forebrain neuroblast division pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, SMC2, and SMC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADATAD2_S342 →+1.164+0.098.001.00137
GBMSMC2 →+0.631+0.136<.001<.00136
LUADSMC4 →+0.521+0.107<.001<.00136
OVTOP2A →+0.871+0.128<.001<.00136
OVTOP2A_S1247 →+1.078+0.117<.001<.00136
LUADCDC20_T70 →+1.216+0.110<.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration