Forebrain ventricular zone progenitor cell division

Across TCGA patient cohorts, RNA activity of the Forebrain ventricular zone progenitor cell division pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGR4-AS1, CYP1A2, and FGFR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Forebrain ventricular zone progenitor cell division activity versus LGR4-AS1 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LGR4-AS1 →	+0.440	+0.347	.001	<.001	3	4
LSCC	CYP1A2 →	-0.060	-0.261	.008	.001	3	3
LUAD	FGFR2 →	+1.043	+0.170	.002	.009	2	4
GBM	LRP4 →	+0.611	+0.833	.002	<.001	3	3
OV	PAX1 →	+0.056	+0.249	.003	.002	3	2
OV	ADM →	+1.685	+0.199	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021869 vs LGR4-AS1 — LSCC

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