Interneuron migration from the subpallium to the cortex

Across TCGA cell cohorts, RNA activity of the Interneuron migration from the subpallium to the cortex pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAT, YPEL1, and RNF38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFAT grouped by Interneuron migration from the subpallium to the cortex-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZFAT →	-2.003	-2.200	<.001	<.001	2	6
LUNG_NSCLC_LUAD	YPEL1 →	-0.816	-0.834	.004	.008	3	4
LUNG_NSCLC_LUAD	RNF38 →	-0.805	-1.219	<.001	<.001	3	4
LUNG_NSCLC_LUAD	EPHB4 →	-0.798	-0.837	.004	.005	3	4
LUNG_NSCLC_LUAD	WDR70 →	-0.620	-1.009	<.001	<.001	3	4
LUNG_NSCLC_LUAD	EFNA2 →	-1.291	-0.950	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFAT by Interneuron migration from the subpallium to the cortex activity — BLOOD_Lymphoma

Explore this box plot interactively →