Interneuron migration from the subpallium to the cortex

Across TCGA pan-cancer cohorts, RNA activity of the Interneuron migration from the subpallium to the cortex pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Interneuron migration from the subpallium to the cortex pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and KIRC, show the opposite pattern, with higher activity associated with better survival.

MESO, BLCA, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.294	0.489	.009	30	view →
BLCA	DFS	Median	II,III,IV	0.420	0.277	.015	29	view →
KIRC	OS	Quartile	II,III,IV	0.748	0.615	.013	25	view →
SCLC	DFS	Tertile	All	0.251	0.821	.003	23	view →
UVM	OS	Median	III,IV	0.652	0.926	.012	22	view →
LIHC	DFS	Tertile	II,III,IV	0.333	0.156	.017	21	view →
UCS	OS	Median	IV	1.000	0.276	.018	18	view →
SKCM	OS	Tertile	III,IV	0.622	0.791	.012	16	view →
READ	DFS	Quartile	All	0.450	0.802	.005	13	view →
KIRP	DFS	Tertile	IV	0.760	0.041	.041	12	view →
ESCA	DFS	Median	All	0.912	0.543	.024	9	view →
ACC	DFS	Median	All	0.600	0.838	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0021830–MESO (OS)

Open the MESO breakdown →