Cell motility involved in cerebral cortex radial glia guided migration

Across TCGA patient cohorts, RNA activity of the Cell motility involved in cerebral cortex radial glia guided migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD11, PRICKLE2-AS3, and BCL2L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell motility involved in cerebral cortex radial glia guided migration activity versus CARD11 in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CARD11 →	-0.706	-0.303	.001	.002	3	4
UCEC	PRICKLE2-AS3 →	+0.497	+0.211	.009	.008	3	4
OV	BCL2L2 →	+0.461	+0.635	.004	.005	3	3
CCRCC	DAB2IP →	+0.821	+0.816	<.001	<.001	3	3
PDAC	MRPS31P5 →	-0.162	-0.395	.006	.001	3	3
UCEC	VASH1-AS1 →	-0.364	-0.335	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021814 vs CARD11 — UCEC

Explore this scatter interactively →