Cell motility involved in cerebral cortex radial glia guided migration

Across TCGA pan-cancer cohorts, RNA activity of the Cell motility involved in cerebral cortex radial glia guided migration pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Cell motility involved in cerebral cortex radial glia guided migration pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

MESO, HNSC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.416	0.692	<.001	87	view →
HNSC	OS	Tertile	IV	0.525	0.192	<.001	60	view →
UVM	DFS	Median	All	0.412	0.756	<.001	55	view →
CESC	DFS	Median	III,IV	0.221	0.607	.008	50	view →
STAD	DFS	Tertile	II,III,IV	0.305	0.586	.004	31	view →
PAAD	OS	Quartile	All	0.238	0.569	<.001	26	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	25	view →
KICH	OS	Tertile	III,IV	1.000	0.527	.004	21	view →
GBM	OS	Quartile	All	0.620	0.238	.009	20	view →
READ	DFS	Tertile	II,III,IV	0.409	0.797	.021	20	view →
LAML	DFS	Median	All	0.471	0.657	.003	18	view →
SKCM	DFS	Tertile	All	0.770	0.580	.012	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0021814–MESO (OS)

Open the MESO breakdown →