Cerebellar granular layer morphogenesis

Across TCGA patient cohorts, RNA activity of the Cerebellar granular layer morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, SMC2, and THOC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cerebellar granular layer morphogenesis activity versus RFC1 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC1 →	+0.311	+0.113	<.001	<.001	3	7
UCEC	SMC2 →	+0.740	+0.121	<.001	<.001	3	7
LSCC	THOC1 →	+0.279	+0.113	.002	<.001	3	7
BRCA	WDR12 →	+0.421	+0.082	<.001	<.001	3	7
UCEC	NUF2_S247 →	+0.863	+0.105	<.001	<.001	3	7
BRCA	PAICS_S27 →	+1.009	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021683 vs RFC1 — UCEC

Explore this scatter interactively →