Facial nerve morphogenesis

Across TCGA patient cohorts, RNA activity of the Facial nerve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALM2AKAP2, BCL6B, and CMAHP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Facial nerve morphogenesis activity versus PALM2AKAP2 in UCEC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALM2AKAP2 →	+0.459	+0.704	<.001	<.001	3	4
UCEC	BCL6B →	+0.488	+0.621	.001	.001	3	4
BRCA	CMAHP →	+0.698	+0.380	<.001	.001	3	4
LUAD	PCDH12 →	+0.308	+0.456	.004	.002	2	5
BRCA	JAM2 →	+0.446	+0.391	.003	<.001	3	4
UCEC	CNRIP1 →	+0.681	+0.590	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021610 vs PALM2AKAP2 — UCEC

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