Vestibulocochlear nerve development

Across TCGA patient cohorts, RNA activity of the Vestibulocochlear nerve development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JCAD, THBS2, and CALD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve development activity versus JCAD in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JCAD →	+0.852	+0.539	<.001	.002	3	5
COAD	THBS2 →	+1.137	+0.623	<.001	.001	3	4
BRCA	CALD1 →	+0.932	+0.644	<.001	<.001	3	4
LSCC	PDLIM5 →	+0.375	+0.521	.004	.008	3	4
LSCC	HMGA2-AS1 →	+0.871	+0.540	<.001	<.001	3	4
LSCC	VCAN →	+0.803	+0.524	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021562 vs JCAD — BRCA

Explore this scatter interactively →