Vestibulocochlear nerve development

Across TCGA cell cohorts, RNA activity of the Vestibulocochlear nerve development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM151B, CFAP299, and PTPN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vestibulocochlear nerve development activity versus FAM151B in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM151B →	+0.516	+1.082	.004	.002	3	4
CNS	CFAP299 →	+0.984	+1.359	.004	<.001	3	4
OVARY	PTPN6 →	-2.196	-1.976	.009	.002	3	3
OVARY	NID1 →	+4.026	+2.162	.001	<.001	3	3
OVARY	RPS2 →	+0.840	+1.673	.003	<.001	3	3
OVARY	CNKSR1 →	-3.082	-2.014	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021562 vs FAM151B — CNS

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