Neural tube patterning

Across TCGA patient cohorts, RNA activity of the Neural tube patterning pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SURF1, ETS2, and DRC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural tube patterning activity versus SURF1 in GBM (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SURF1 →	+0.201	+0.427	.005	<.001	3	3
PDAC	ETS2 →	-0.466	-0.425	.003	.008	3	3
BRCA	DRC3 →	+0.736	+0.702	.004	.002	3	3
LSCC	SOCS3 →	-0.540	-0.812	.005	.001	3	3
LSCC	RNA5SP53 →	+0.681	+0.901	.002	.001	3	3
LSCC	HMGN2P15 →	+0.748	+0.738	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021532 vs SURF1 — GBM

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