Neural tube patterning

Across TCGA cell cohorts, RNA activity of the Neural tube patterning pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D3L, ZC3H3, and RPUSD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D3L grouped by Neural tube patterning-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TBC1D3L →	-2.062	-2.164	.005	<.001	3	4
URINARY_TRACT	ZC3H3 →	-0.744	-2.030	<.001	<.001	3	3
URINARY_TRACT	RPUSD3 →	-0.797	-1.814	.007	<.001	3	3
PANCREAS	FKBP8 →	-0.565	-1.389	.008	<.001	2	4
PANCREAS	COQ5 →	-0.694	-1.308	.002	.002	3	3
PANCREAS	SRSF9 →	-0.757	-1.274	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D3L by Neural tube patterning activity — LIVER

Explore this box plot interactively →