Spinal cord association neuron differentiation

Across TCGA cell cohorts, RNA activity of the Spinal cord association neuron differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR74, SCRIB, and HOXC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR74 grouped by Spinal cord association neuron differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WDR74 →	-0.372	-1.259	.003	.006	3	4
KIDNEY	SCRIB →	+0.325	+1.219	.008	.004	2	4
BLOOD_Myeloma	HOXC12 →	-0.201	-0.180	.001	.009	3	3
LARGE_INTESTINE	SNRPG →	+0.281	+0.208	<.001	<.001	3	3
CNS	BIRC6 →	+0.251	+0.928	<.001	.006	3	3
LIVER	RIOX2 →	+0.175	+1.429	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR74 by Spinal cord association neuron differentiation activity — CNS

Explore this box plot interactively →