Spinal cord association neuron differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Spinal cord association neuron differentiation pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher Spinal cord association neuron differentiation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CHOL and ACC, show the opposite pattern, with higher activity associated with better survival.

CHOL, ACC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	DFS	Tertile	All	0.750	0.147	.001	48	view →
ACC	DFS	Tertile	All	0.657	0.233	<.001	45	view →
KIRC	DFS	Median	All	0.736	0.524	<.001	42	view →
SCLC	OS	Tertile	All	0.553	0.794	.008	38	view →
THCA	DFS	Median	II,III,IV	0.903	0.766	.002	36	view →
READ	OS	Median	III,IV	0.396	0.955	<.001	33	view →
UVM	OS	Median	All	1.000	0.769	.008	30	view →
STAD	DFS	Quartile	IV	0.123	0.433	.002	18	view →
UCEC	DFS	Median	All	0.867	0.927	.009	18	view →
SKCM	OS	Tertile	IV	1.000	0.234	.024	16	view →
ESCA	OS	Median	All	0.767	0.622	.027	14	view →
COAD	OS	Median	All	0.875	0.738	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0021527–CHOL (DFS)

Open the CHOL breakdown →