Ventral spinal cord development

Across TCGA cell cohorts, RNA activity of the Ventral spinal cord development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPR2, CCNT1, and C3orf18, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GMPR2 grouped by Ventral spinal cord development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GMPR2 →	-0.809	-1.437	.009	.008	3	3
LIVER	CCNT1 →	+0.534	+1.364	.008	.005	3	3
LIVER	C3orf18 →	-1.608	-1.396	.002	.002	3	3
BREAST	GPRIN2 →	+1.322	+0.286	<.001	.002	3	3
BONE	PDZK1IP1 →	-0.219	-1.313	.009	.002	3	3
CNS	CPSF4 →	-0.558	-0.740	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GMPR2 by Ventral spinal cord development activity — LIVER

Explore this box plot interactively →