Ventral spinal cord development

Across TCGA pan-cancer cohorts, RNA activity of the Ventral spinal cord development pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 46 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Ventral spinal cord development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, UCS, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.480	0.290	.002	38	view →
UCS	OS	Median	All	0.867	0.545	.005	36	view →
LGG	OS	Quartile	All	0.706	0.430	<.001	36	view →
READ	OS	Median	III,IV	0.283	0.725	<.001	35	view →
ESCA	OS	Tertile	II,III,IV	0.797	0.548	.003	32	view →
OV	DFS	Median	III,IV	0.575	0.502	.017	28	view →
KIRC	OS	Quartile	All	0.916	0.833	.008	17	view →
LUSC	DFS	Median	III,IV	0.506	0.886	.010	9	view →
CHOL	DFS	Tertile	All	1.000	0.161	.035	9	view →
LIHC	OS	Tertile	III,IV	0.305	0.768	.002	9	view →
SCLC	DFS	Quartile	All	0.463	0.697	.029	8	view →
TGCT	DFS	Quartile	All	0.569	0.803	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0021517–MESO (DFS)

Open the MESO breakdown →